Sulfated Polysaccharides enhance anti-ageing activity by the inhibition of skin deterioration enzymes.
As the largest organ of the human being, the skin acts as a protective barrier by isolating the organism from its surrounding environment and helping to maintain the integrity of all the inner structures and at the same time serve as a communication system with the environment. However, beyond its biological function, the skin plays an important role in the health of humans, greatly defining their image, allowing them to be or not in harmony with the beauty standards of today's society. Biochemical changes, which are unleashed by the aging process in addition to external agents, induce such damages on skin as the appearance of wrinkles, spots, loss of elasticity and firmness, inflammation, and thinning of the dermal matrix.
The main biochemical imbalance produced is the increased activity of collagenase, elastase, and hyaluronidase enzymes. This imbalance leads to an accelerated degradation of the three major components of the skin: collagen (protein responsible for giving firmness), elastin (protein that gives elasticity) and hyaluronic acid (glycosaminoglycan, which gives volume due to water retention).
Another significant alteration caused by ageing and by certain environmental factors (solar radiation, pollution, climate, etc.) is the high generation of reactive oxygen species (ROS) such as the hydroxyl radical and the superoxide anion, involved in mutagenesis, carcinogenesis and ageing itself. The use of a substance providing protection against oxidative stress and inhibiting also the activity of these enzymes could lead to a better dermal matrix, improving the health and appearance of skin. For this reason, various substances have been studied for several decades in order to know their ability to inhibit collagenase, elastase, and hyaluronidase.
Natural Sulfated Polysaccharides extracted from Porphyridium have shown significant inhibition activity of both hyaluronidase and of elastase enzymes, and therefore possess powerful anti ageing characteristics.
Scientific Literature References
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