Natural Sulfated Polysaccharides

Sulfated Polysaccharides enhance anti-ageing activity by the inhibition of skin deterioration enzymes.

As the largest organ of the human being, the skin acts as a protective barrier by isolating the organism from its surrounding environment and helping to maintain the integrity of all the inner structures and at the same time serve as a communication system with the environment. However, beyond its biological function, the skin plays an important role in the health of humans, greatly defining their image, allowing them to be or not in harmony with the beauty standards of today's society. Biochemical changes, which are unleashed by the aging process in addition to external agents, induce such damages on skin as the appearance of wrinkles, spots, loss of elasticity and firmness, inflammation, and thinning of the dermal matrix.

The main biochemical imbalance produced is the increased activity of collagenase, elastase, and hyaluronidase enzymes. This imbalance leads to an accelerated degradation of the three major components of the skin: collagen (protein responsible for giving firmness), elastin (protein that gives elasticity) and hyaluronic acid (glycosaminoglycan, which gives volume due to water retention).

Another significant alteration caused by ageing and by certain environmental factors (solar radiation, pollution, climate, etc.) is the high generation of reactive oxygen species (ROS) such as the hydroxyl radical and the superoxide anion, involved in mutagenesis, carcinogenesis and ageing itself. The use of a substance providing protection against oxidative stress and inhibiting also the activity of these enzymes could lead to a better dermal matrix, improving the health and appearance of skin. For this reason, various substances have been studied for several decades in order to know their ability to inhibit collagenase, elastase, and hyaluronidase.

Natural Sulfated Polysaccharides extracted from Porphyridium have shown significant inhibition activity of both hyaluronidase and of elastase enzymes, and therefore possess powerful anti ageing characteristics.

Scientific Literature References

  1.  Activity of Sulfated Polysaccharides from Microalga Porphyridium cruentum over Degenerative Mechanisms of the Skin, Kenny C. DÍAZ BAYONA, Sandra M. NAVARRO G. , Andrés D. LARA E., Jhonny COLORADO R., Lucía ATEHORTÚA G., Alejandro MARTÍNEZ M.; International Journal of Science and Advanced Technology (ISSN 2221-8386) Volume 2 No 8 August 2012
  2. A Natural Sulfated Polysaccharides From Porphyridium Cruentum Red Microalgae A Potential Mimic Of Heparan Sulfate And Its Modulation Of The Epidermal Biologocal Activity Of Human Reconstructed Skin, M. Ghibaudo, C. Baltenneck, A.-M. Minondo, L. Tournier Couturier, A. Potter, L’Oréal Research & Innovation, Aulnay-sous-bois, France
  3. Superior Biolubricant from a Species of Red Microalga, Shoshana Malis Arad et. Al , Langmuir 22(17):7313-7 · September 2006
  4. Bioactivity and Applications of Sulfated Polysaccharides from Marine Microalgae, Mar Drugs. 2013 Jan; 11(1): 233–252, Maria Filomena de Jesus Raposo et al.
  5. Red microalgal cell-wall polysaccharides: biotechnological aspects. Current Opinion in Biotechnology, Volume 21, Issue 3, Pages 358-364. Shoshana (Malis) Arad, Oshrat Levy-Ontman
  6. Isolation and characterization of poly- and oligosaccharides from the red microalga Porphyridium sp. Carbohydrate Research, Volume 344, Issue 3, 17 February 2009, Pages 343–349, Shimona Geresh, Shoshana (Malis) Arada, Oshrat Levy-Ontmana, Wang Zhang, Yoram Tekoah,, Robert Glaser
  7. The sulfated polysaccharide from a marine red microalga as a platform for the incorporation of zinc ions., Netanel Liberman G, Ochbaum G, Malis Arad S, Bitton R. Carbohydr Polym. 2016 Nov 5;152:658-64. doi: 10.1016/j.carbpol.2016.07.025. Epub 2016 Jul 17.